Complex roles of endothelial shear stress in vascular remodeling response.
نویسنده
چکیده
improves vascular endothelial and cardiac function in patients with chronic heart failure. J Am Coll Cardiol 2002;39:754–9. 4. Akasaki Y, Miyata M, Eto H, et al. Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. Circ J 2006:70;463–70. 5. Aicher A, Heeschen C, Mildner-Rihm C, et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003;9:1370–6. 6. Tei C, Shinsato T, Kihara T, Miyata M. Successful thermal therapy for end-stage peripheral artery disease. J Cardiol 2006;47:163–4.
منابع مشابه
Metalloproteinases, Mechanical Factors and Vascular Remodeling
Chronic increases in arterial blood flow elicit an adaptive response of the arterial wall, leading to vessel enlargement and reduction in wall shear stress to physiological baseline value. Release of nitric oxide from endothelial cells exposed to excessive shear is a fundamental step in the remodeling process, and potentially triggers a cascade of events, including growth factor induction and m...
متن کاملCCM proteins control endothelial β1 integrin dependent response to shear stress
Hemodynamic shear stress from blood flow on the endothelium critically regulates vascular function in many physiological and pathological situations. Endothelial cells adapt to shear stress by remodeling their cytoskeletal components and subsequently by changing their shape and orientation. We demonstrate that β1 integrin activation is critically controlled during the mechanoresponse of endothe...
متن کاملVascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point
Vascular remodeling under conditions of growth or exercise, or during recovery from arterial restriction or blockage is essential for health, but mechanisms are poorly understood. It has been proposed that endothelial cells have a preferred level of fluid shear stress, or 'set point', that determines remodeling. We show that human umbilical vein endothelial cells respond optimally within a rang...
متن کاملPECAM-1 is necessary for flow-induced vascular remodeling.
OBJECTIVE Vascular remodeling is a physiological process that occurs in response to long-term changes in hemodynamic conditions, but may also contribute to the pathophysiology of intima-media thickening (IMT) and vascular disease. Shear stress detection by the endothelium is thought to be an important determinant of vascular remodeling. Previous work showed that platelet endothelial cell adhesi...
متن کاملEven flow: shear cues vascular development.
The appreciation that biomechanical forces induce signaling responses that regulate vascular tone and inflammatory responses has had a paradigm-shifting effect on our understanding of vascular biology. Endothelial cells are constantly exposed to rheologically imposed forces that vary due to vascular anatomic features and hemodynamic parameters, and of course shear fluctuates cyclically during t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of the American College of Cardiology
دوره 50 22 شماره
صفحات -
تاریخ انتشار 2007